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NAME
Delavirdine |
BRAND
Rescriptor |
CLASS
Non-nucleoside analog (also called non-nucleoside reverse transcriptase inhibitor, NRTI or non-nuke) |
COST
$3,504/yr., $292/month |
STANDARD DOSE
Two 200 mg tablets (smaller than the 100-mg) three times a day, no food restrictions. Take missed dose as soon as possible but do not double the dose. |
POTENTIAL SIDE EFFECTS
Rash, headache, nauseas, vomiting, diarrhea, fatigue, and pruritus (itchy skin) severe rash observed in NRTI class could be life threatening. Signs may include fever, blistering, oral lesions, conjunctivitis (pink eye, which if untreated may result in permanent loss of vision) swelling, muscle, or joint aches or general malaise (feeling unwell, as with flu) stop taking Rescriptor if these symptoms appear and seek immediate medical attention. |
POTENTIAL DRUG INTERACTIONS
Do not use Zocor (simvastin) or Mevacor (lovatatin) lipid lowering agents; suggested alternatives are Liptiro (atoveastian) Lescol (fluvastatin) Baycol (cerivastian) and Pravachol (pravastiatin, the one that looks best on paper for people on protease inhibitor) alternatives should still be used with caution because of potential for liver toxicity. Seldane (trefenadine) Hismanal (astemizole) Versed (mizaolam) and Xanax (alprozolam) should not be used concurrently with Rescriptor. Potential toxicity when given Biaxin (claruthromycin) dapsone, Mycobutin (rifabutin), ergot derivatives (such as Wigraine and Cafergot, in any form-serious interactions seen with dilation during gynecological exams) procardia (nitedipine), Coumadin (warfarin) and quindine. Tegretol (carbmazepine, an anti-seizure medication used to treat perheral neuropathy) Phenobarbital, Dilantin (phenytoin) MYCOBUTIN (RIFABUTIN) and rifampin (under various brand names, used to treat tuberculosis) are drugs that decrease Rescriptor levels. Certain amphetamines and antirrhythmics drugs should not be used with Rescriptor. Use of Tagamet and other drugs in that class is not recommended because they may reduce the absorption of Rescriptor. Rescriptor increases Crixivan, Fortovase, and invirase levels. Absorption of Rescriptor is decreased with antacids, including Videx (because of its antacid buffer) so take one hour apart from these drugs. Prescribed may need to adjust doses of all these drugs accordingly. |
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