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NAME
Tenofovir disoproxil fumarate |
BRAND
Viread |
CLASS
Nucleotide analog (also called nucleotide reverse transcriptase inhibitor, NRTI or nuke) |
COST
$4,896/yr., $408/month |
STANDARD DOSE
One 300 mg tablet once a day, with food. |
POTENTIAL SIDE EFFECTS
Grade 3 or 4 (serious) increased creatine (a sign of kidney or muscle damage) and AST/ALT(Liver function tests, a sign of liver damage) and AST/ALT (liver function test, a sign of liver damage) showed in lab reports. In one study, serious side effects ranged from 6 10 16%. Elevation of creatine phophokinase (CPK). Also nausea, headache, diarrhea, vomiting, asthenia, flatulence, abdominal pain and anorexia, Rare but potentially fatall toxicity with all NRTIs pancreatitis (signs include nausea, vomiting, and abdominal pain that often spreads to the chest and back); lactic acidosis (seen mostly in women, especially obese women; greater risk for people with underlying liver disease; signs include deep muscle fatigue, especially in legs and difficulty breathing) and enlarge, fatty liver (called heptamegaly with steatosis; check for tenderness below the ribs on right side.) |
POTENTIAL DRUG INTERACTIONS
No concomitant nephrototoxic drugs allowed for small compassionate access program. Such drugs include Crixivan, Viracept, Ziagen, Hydroxyurea, Zovirax, Cytovene, Mepron, and streptomycin (used rarely for tuberculosis) until more studies are conducted caution is urged when using Viread with drugs causing renal toxicity, such as foscarnet, pentamidine, and cidofovir. |
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